卡维地洛的使用与肝硬化腹水患者生存改善的相关性

Correlation between carvedilol use and survival improvement in patients with cirrhosis ascites

目的:探讨卡维地洛与肝硬化腹水患者生存改善的相关联系。方法:收治肝硬化腹水患者140例,分为对照组和观察组。对照组采用普萘洛尔治疗,观察组采用卡维地洛治疗,比较两组治疗效果。结果:观察组年龄、BMI及肝静脉压力梯度下降值高于对照组,观察组上消化道静脉破裂再出血率及累计生存率都优于对照组,服用卡维地洛是患者生存的保护性因素。结论:卡维地洛能显著改善肝硬化患者上消化道静脉破裂和肝硬化腹水情况,明显提高肝脏相关存活率。

Objective:To explore the correlation between carvedilol use and survival improvement in patients with cirrhosis ascites.Methods:140 patients with cirrhosis ascites were selected.They were divided into the control group and the observation group.The control group was treated with propranolol.The observation group was treated with carvedilol we compared the therapeutic effect of two groups.Results:In the observation group,the age,BMI and the gradient of the pressure gradient descending value of hepatic vein were all higher than those in the control group.The ruptured and rebleeding rate of upper gastrointestinal vein and the cumulative survival in the control group were lower than the observation group.Taking carvedilol was a protective factor for the survival of the patient.Conclusion:Carvedilol can significantly improve the upper gastrointestinal venous rupture and ascites in the liver cirrhosis,and significantly improve the liver related survival rate.