不同肾小球滤过率计算公式预测心血管事件风险的价值

Value of Different Glomerular Filtration Rates to Predict the Risk of Cardiovascular Events

慢性肾脏病(CKD)已成为世界范围内的公共卫生问题,其患病率逐年增加。CKD患者的预后不佳,不仅局限于CKD可导致患者肾衰竭需进行长期维持性透析或接受肾脏移植手术,还包括由此带来的各种心血管疾病及死亡风险。而肾小球滤过率(GFR)是反映肾脏功能、评价肾脏疾病进展和严重程度最重要的指标。截至目前,GFR的评估公式很多,包括CG公式、MDRD公式及近年来广泛应用的慢性肾脏病流行病学合作研究组(CKD-EPI)提出的CKD-EPI公式等。因此,应用哪种评估公式可以更好地预测心血管事件的发生风险成为近年流行病学研究的重点。鉴于目前关于CKD预后的研究人群中纳入高龄和合并慢性疾病的人群比例较高,因此未来的研究应针对所有人群,评价不同的GFR计算公式在肾功能评估和风险预测中的价值。

Chronic kidney disease(CKD)has become a worldwide public health problem and its prevalence rate has been increasing year by year.The prognosis of CKD patients is poor,which is not only limited to CKD,but also leads to long-term renal failure and long-term renal maintenance.It also includes all kinds of cardiovascular diseases and death risk.Glomerular filtration rate(GFR)is the most important indicator reflecting the kidney function and evaluating the severity of kidney disease progression.Up to now,there are many evaluation formulas of GFR,including CG(Cockcroft-Gault)formula,MDRD(Modification of Diet in Renal Disease)formula and the widely used formula of Chronic Kidney Disease Epidemio-logy Collaboration(CKD-EPI)proposed in recent years.Therefore,which assessment formula can better predict the risk of cardiovascular events has become the focus of epidemiological studies in recent years.In view of the high proportion of elderly people and high incidence of chronic diseases who have been enrolled in the study of CKD prognosis,we should evaluate different GFR formulas in renal function assessment and risk prediction for all groups.