狼疮性肾炎的治疗进展

Recent Advances in Treatment of Lupus Nephritis

狼疮性肾炎(LN)是系统性红斑狼疮(SLE)最严重的并发症之一,对患者的生存质量以及长期预后影响很大。LN的治疗包括激素治疗(糖皮质激素)和免疫抑制剂(环磷酰胺、吗替麦考酚酯、硫唑嘌呤、来氟米特等)治疗。随着医学的发展以及研究的深入,LN治疗的新型制剂、新的治疗方法不断涌现,如生物制剂、中医中药血液净化及干细胞移植等,了解这些治疗方法、治疗药物的适用人群、使用方法、不良反应等将有助于提高LN的规范化、个体化治疗,改善患者的生存质量、延长存活时间。

Lupus nephritis(LN)is one of the most serious complications of systemic lupus erythematosus(SLE),which has a great influence on patients′quality of life and long-term prognosis.The treatment of LN includes hormone therapy(corticosteroids)and immunosuppressive therapy(cyclophosphamide,mycophenolate mofetil,azathioprine,leflunomide etc.).With the development of medical science and research,new treatment preparations and methods are constantly emerging,such as biological agents,Chinese medicine and blood purification and stem cell transplantation.Understanding the applicable population,usage and adverse reactions of these treatments and drugs can help to set up the standards of LN individualized treatment,and improve the quality of life and the survival time of patients.