肠道稳态失调与肝脏疾病的关联

Relationship between Intestinal Dysregulation and Liver Disease

肠道稳态的平衡包括肠道菌群的稳定和肠道物理、免疫屏障的稳定。在药物、酗酒、饮食、肝脏疾病等因素的作用下,肠道稳态的平衡可能遭到破坏。由于肝脏和肠道通过肝肠轴相连,肠道稳态失调能够引起肠道菌群异位,使肝脏直接暴露于肠源性内毒素血症的攻击,加重肝脏炎症反应,引起肝纤维化,甚至诱发肝癌。因此,肝脏疾病和肠道稳态失调有相互联系、相互促进的特点。应用微生态制剂、抗生素及胃肠动力药改善肠道稳态失调能够为肝脏疾病的治疗提供帮助。特定肠道菌种的提取与相关诊治也为肝脏疾病的诊断和治疗提供新的视角。

The balance of intestinal homeostasis includes the stability of the intestinal flora,the intestinal physics and the stability of the immune barrier.The balance of intestinal homeostasis may be damaged by factors such as drugs,alcohol,diet,and liver disease.Because the liver and intestinal connected through the enterohepatic axis,intestinal homeostasis can cause ectopia of intestinal flora,exposing liver directly to intestinal endotoxemia attacks,aggravating the inflammation of the liver and causing liver fibrosis,even inducing liver cancer.Therefore,the liver disease and intestinal homeostasis are interrelated and mutually promoting.The application of microecological agents,antibiotics and gastrointestinal motility drugs to improve intestinal homeostasis can provide help for the treatment of liver diseases.The extraction and related diagnosis and treatment of specific intestinal bacteria also provide a new angle for the diagnosis and treatment of liver diseases.