摘要
以3-卤氧化吲哚为起始原料,DMAP为有机催化剂,在甲苯中于60℃和苄胺发生3-胺基化取代反应后,用Boc基团对氮原子进行保护,合成了7个新型的N-Boc-3-胺基四取代氧化吲哚,收率85%~93%,其结构经~1H NMR,^(13)C NMR和HR-MS(ESI-TOF)表征。
Seven novel N-Boc 3-amino tetrasubstituted oxindole scaffolds,in yields of 87%~92%,were synthesized by the reaction of 3-halooxindoles with benzylamine in toluene at 60℃,using DMAP as orangic catalyst,and then protection with(Boc)2O.The structures were characterized by 1 H NMR,13 C NMR and HR-MS(ESI-TOF).
作者
杨楷模
刘欢欢
陈智勇
刘雄利
俸婷婷
余章彪
YANG Kai-mo;LIU Huan-huan;CHEN Zhi-yong;LIU Xiong-li;FENG Ting-ting;YU Zhang-biao(Guizhou Medicine Edicine Edible Plant Resources Research and Developmant Center,Guizhou University,Guiyang 550025,China)
出处
《合成化学》
CAS
CSCD
北大核心
2018年第4期276-279,共4页
Chinese Journal of Synthetic Chemistry
基金
贵州省科技计划项目(黔科合基础[2017]1035)
贵州省教学改革创新项目(黔教研合JG字[2016]06)
