丹参酮ⅡA磺酸钠注射液联用地高辛治疗老年人心衰临床疗效研究

A clinical analysis of tanshinone ⅡA injections mixed with digoxin in treatment of elderly with heart failure

目的:探讨丹参酮ⅡA磺酸钠注射液联合地高辛治疗老年人心衰的临床疗效。方法:195例老年心衰患者随机分为两组,在利尿、扩血管等其它方式治疗的基础上,试验组(98例)采用地高辛联合丹参酮ⅡA磺酸钠注射液治疗,对照组(97例)给予地高辛治疗。观察两组地高辛血药浓度差别及用药后心肾功能相关指标的变化。结果:治疗前两组患者年龄、性别、心功能等指标差异无统计学意义(P>0.05),治疗后两组患者的心功能和肾功能(尿素氮、肌酐、尿酸)均有改善,且试验组改善更为明显,两组比较差别有统计学意义(P<0.05),而地高辛浓度两组差异无统计学意义(P>0.05)。结论:地高辛联合丹参酮ⅡA磺酸钠注射液治疗老年人心衰具有较好的临床疗效,降低了用药风险,是老年心衰患者治疗方案的优良选择。

Objective:To analyse the clinical value of tanshinoneⅡA injections mixed with digoxin in treatment of elderly with heart failure.Methods:195 elderly heart failure patients were randomly divided into two groups.Experimental group were given tanshinoneⅡA injections mixed with digoxin and the control group were given equal volume of digoxin.The heart and kidney function were compared between different stage.To investage the digoxin concentration of the two groups.Results:There were 98 cases in experimental group and 97 cases in control group,and no significant difference was found between genders,age,cardiac function.Difference of uric acid,blood urea nitrogen(BUN)and creatinine were significant between the experimental group and the control group.Patients in experimental group achieve a higher efficacy on cardiac and renal function,and have no significant affection on the concentration of digoxin.Conclusion:TanshinoneⅡA injections mixed with digoxin is a better choice for elderly heart failure patients,it is of great importance to ensure clinical efficacy and reduce risk of toxic reaction.