摘要
DNA折纸技术是近年来新提出的一种DNA自组装方法,可设计特定的DNA序列,遵循碱基互补配对原则来构建出更为复杂的纳米结构与纳米图案。近期发现通过DNA折纸技术构建出的DNA四面体纳米结构(TDN)在干细胞领域有着巨大应用潜能。本文就TDN结构、生物学特性以及在干细胞领域的应用进行综述。
DNA origami is a newly proposed DNA self-assembly method in recent years.It can design specific DNA sequences and follow the principle of complementary base pairing to construct more complex nanostructures and nanopatterns.The recent discovery of tetrahedral DNA nanostructure(TDN)constructed by DNA origami has great application potential in the field of stem cells.In this study,we reviewed the structure and biological properties of TDN,and the applications of TDN in the field of stem cells.
作者
林云锋
李松航
Lin Yunfeng;Li Songhang(State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&Dept.of Oral and Maxillofacial Surgery,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China)
出处
《国际口腔医学杂志》
CAS
CSCD
2018年第3期249-254,共6页
International Journal of Stomatology
关键词
DNA纳米结构
DNA四面体
干细胞
分化
组织再生
DNA nanostructure
tetrahedral DNA nanostructure
stem cell
differentiation
tissue regeneration
