硅酸镁锂在骨组织工程中的研究进展

Research progress on synthetic nanosilicates in bone tissue engineering

硅酸镁锂是一种纳米黏土材料,因其具有的细胞水平大小、带电片晶结构和较高的表体积比,易与蛋白分子、细胞、聚合物交联。随着对硅酸镁锂研究的不断深入,近年来该材料已逐渐发展到骨组织工程领域。本文以硅酸镁锂的物理化学性质和生物学性质为基础,对骨组织工程中硅酸镁锂对种子细胞功能调控、生长因子递载以及基质材料改良的研究进展作一综述,以期为该材料在骨组织工程中的应用研究提供参考。

Synthetic nanosilicates are clay nanoparticles that have a cellular-level size,distinct charged and layered structure,and high surface-to-volume ratio,which enhances their interactions with proteins,cells,and polymers.Recently,researchers have focused on the implications of using synthetic nanosilicates in bone tissue engineering to understand their physicochemical and biological properties.The scope of this review includes the well-established use of synthetic nanosilicates for the adjustment of cell functions during bone tissue engineering.The interactions of synthetic nanosilicates with growth factors enable controlled delivery,and their mechanical or biological properties are enhanced when they interact matrix materials.This review is useful to future studies on synthetic nanosilicates.