儿童EB病毒感染相关性肾损伤临床特点分析

Analysis of clinical features of renal injury associated with EB virus infection in children

目的分析儿童EB病毒感染相关性肾损伤的临床特点,为早期临床干预提供理论依据。方法选取2014年1月-2016年1月在西南医科大学附属医院儿科住院的确诊为EB病毒感染的237例患儿的临床资料,其中合并肾损伤的57例患儿为肾损组,不合并肾损伤的180例患儿为非肾损组。以患儿入院为观察起点,出院为观察终点,分析比较两组患儿在年龄、性别、病程、热程及实验室检查指标,包括丙氨酸氨基转氨酶(ALT)、门冬氨酸氨基转氨酶(AST)、白细胞计数(WBC)、异型淋巴细胞率(VLYM)、抗EB病毒抗体等的差异,并将其结果进行统计学分析。结果 237例患儿中肾损伤57例(24.05%),其中镜下血尿18例(7.59%)、蛋白尿51例(21.52%)、血尿+蛋白尿10例(4.22%),不同性别、年龄、病程、热程及实验室检查在两组间比较,差异无统计学意义(P>0.05)。结论 EB病毒感染引起的肾损伤临床发生率较高,以蛋白尿为主。

Objective To explore the clinical features of childhood Epstein-Barr virus infection associated renal injury,in order to find grounds for timely treatment.Methods A total of 237 cases with Epstein-Barr virus infection admitted to the Department of Pediatrics in the Affiliated Hospital of Southwest Medical University from January 2014 to January 2016 were selected and divided into renal injury group(57 cases)and non-renal injury group(180 cases).The period of observation for the children was between the admission time and discharge time.The age,sex,course of disease,fever lasting time and laboratory findings(including glutamic-pyruvic transaminase,glutamicoxalacetic transaminase,leukocyte count,rate of variant lymphocytes,anti-EB antibody,etc)were compared between the two groups and statistically analyzed.Results Of the 237 patients,57(24.26%)patients were confirmed with renal injury,18 cases(7.6%)had microscopic hematuria,51 cases(21.52%)had proteinuria,10 cases(4.22%)had both microscopic hematuria and proteinuria.There was no obvious difference between the two groups in age,sex,course of disease,fever lasting time or any laboratory finding(P>0.05).Conclusions The incidence of renal injury associated with Epstein-Barr virus infection is high,mainly presented with proteinuria.