骨形态发生蛋白2在黄韧带骨化发生和发展中的作用

Role of bone morphogenetic protein 2 in occurrence and development of ligamentum flavum ossification

黄韧带骨化是胸椎管狭窄的主要原因,其起病隐匿,出现症状时多造成脊髓严重压迫,临床治疗效果不理想,因此亟需研发针对黄韧带骨化早期诊治和预后监测的有效手段。骨形态发生蛋白2(BMP-2)属于转录生长因子β家族成员,在胚胎发育早期阶段诱导间充质干细胞成骨分化和软骨内成骨过程中发挥关键调节作用。研究表明黄韧带骨化,尤其是连续多水平的黄韧带骨化与BMP-2关系密切。本文对BMP-2在黄韧带骨化发生和发展中的作用机制作一综述,希望能为黄韧带骨化的早期诊治和预后监测提供新的思路。

The ossification of ligamentum flavum(OLF)is a major cause of thoracic spinal stenosis.Due to insidious onset,OLF usually results in severe compression of spinal cord when discovered,and the clinical outcomes are poor.Therefore,novel and effective diagnostic and therapeutic approaches for OLF are greatly needed.Bone morphogenetic protein 2(BMP-2),a member of the transforming growth factorβfamily,possesses a critical role in the differentiation of mesenchymal stem cells towards osteoblastic lineage and endochondral ossification in the early stage of embryonic development.Increasing researches revealed that OLF,especially the continuous multilevel ossification,correlates closely with BMP-2.In this review,we summarized the advances on the role of BMP-2 in the occurrence and development of OLF,and prospected the application of BMP-2 as a potential target in the diagnosis,therapy and prognosis monitoring of OLF.