非编码RNA在溃疡性结肠炎中作用的研究进展

Advances in Study on Role of Non-coding RNA in Ulcerative Colitis

溃疡性结肠炎(UC)是一种主要累及结直肠的慢性非特异性炎症性疾病,其病因尚未完全明确,常反复发作,并可发生癌变。非编码RNA(ncRNA)如微RNA(microRNA)、长链ncRNA(lncRNA)、环状RNA(circRNA)等在机体生长、发育以及疾病发生、发展中发挥重要作用。ncRNA可通过促进炎症细胞浸润、削弱肠黏膜屏障功能、诱导肠上皮细胞凋亡等多种机制,引起UC发生,并参与其癌变。本文就ncRNA在UC中作用的研究进展作一综述。

Ulcerative colitis(UC)is a chronic non-specific inflammatory disease involving colon and rectum,and its etiology is not yet fully defined.UC is recurrent and can develop into colorectal cancer.Non-coding RNA(ncRNA)such as microRNA,long non-coding RNA(lncRNA),circular RNA(circRNA)plays a significant role in the process of growth and development of diseases.NcRNA can induce UC via promoting inflammatory cell infiltration,weakening intestinal mucosal barrier function and inducing intestinal epithelial cell apoptosis,and participate in its cancerization.This article reviewed the advances in study on role of ncRNA in UC.