米诺环素软膏与甲硝唑凝胶局部应用治疗牙周炎研究

Local Application of Minocycline Ointment and Metronidazole Gel in the Treatment of Periodontitis

目的:探讨局部应用米诺环素软膏与局部应用甲硝唑凝胶治疗牙周炎的治疗效果。方法:从许昌市第二人民医院选取2011年到2014年收治的116例牙周炎患者进行研究,采用随机数字表法将所有患者分为2组,每组58例,对照组采用木诺环素软膏进行治疗,观察组采用甲硝唑进行治疗,对比分析两组患者牙周炎指数变化情况、治疗效果、不良反应、炎症因子水平变化情况、疼痛程度评分和不良情绪评分。结果:观察组患者采用米诺环素软膏进行治疗后,观察组患者牙周炎指数变化情况、不良反应、炎症因子水平变化情况、疼痛程度评分和不良情绪评分低于对照组,观察组治疗效果高于对照组,两组间差异明显P<0.05。结论:比较对牙周炎患者局部应用米诺环素软膏与局部应用甲硝唑凝胶的治疗效果后发现,局部应用米诺环素软膏对牙周炎患者进行治疗,可有效改善患者临床症状,降低不良反应发生率,有利于提高治疗效果,综合效应比较好,安全性高,值得应用。

Objective:To investigate the therapeutic effect of local minocycline ointment and metronidazole gel in the treatment of periodontitis.Methods:116 patients with periodontitis admitted from 2011 to 2014 were randomly divided into two groups,58 cases in each group.The control group was treated with minocycline ointment.The patients in the observation group were treated with metronidazole.The changes of periodontitis index,therapeutic effect,adverse reaction,inflammatory factor level,pain score and adverse emotion score were compared between the two groups.Results:The patients in the observation group were treated with minocycline ointment.After treatment,the changes of periodontitis index,adverse reaction,inflammatory factor level,pain score and adverse emotion score in the observation group were lower than those in the control group,and the therapeutic effect in the observation group was higher than that in the control group,with a significant difference between the two groups(P<0.05).Conclusion:After comparing the effect of local minocycline ointment and metronidazole gel in the treatment of periodontitis,it is found that the local application of minocycline ointment can effectively improve the clinical symptoms of patients with periodontitis.Reducing the incidence of adverse reactions is beneficial to improve the therapeutic effect.The comprehensive effect is better and the safety is high.