吸入激素联合噻托溴铵治疗哮喘-慢阻肺重叠综合征的临床效果

Clinical effect of inhaled hormone combined with Tiotropium Bromide in the treatment of asthma chronic obstructive pulmonary overlap syndrome

目的研究哮喘-慢阻肺重叠综合征(ACOS)吸入激素联合噻托溴铵治疗的临床效果。方法选取2016年1月~2017年6月在我院接受治疗的100例符合ACOS诊断标准的患者,将其按照治疗药物的不同分为舒利迭联合噻托溴铵吸入剂组(试验组)60例与舒利迭吸入剂组(对照组)40例。对比两组治疗前后肺功能指标,对两组治疗前后哮喘症状评分、慢阻肺症状评分和急性加重次数进行比较,并比较两组不良反应发生情况。结果两组治疗前肺功能比较,差异无统计学意义(P>0.05);治疗后,两组肺功能均得到一定改善,但治疗后试验组肺功能指标优于对照组,差异有统计学意义(P<0.05)。两组治疗前哮喘症状(ACT)评分、慢阻肺评估测试评分(CAT)和急性加重次数差异无统计学意义(P>0.05),治疗后两组ACT、CAT评分均明显下降,急性加重次数明显减少,但治疗后试验组ACT、CAT评分及急性加重次数均优于对照组,差异有统计学意义(P<0.05)。两组药物不良反应发生率比较,试验组低于对照组,差异有统计学意义(P<0.05)。结论 ACOS吸入舒利迭联合噻托溴铵治疗效果较好,能明显改善患者预后效果。

Objective To study the clinical effect of asthma and COPD overlap syndrome(ACOS)of inhaled corticosteroid combined with Tiotropium therapy.Methods From January 2016 to June 2017,100 patients who met the criteria for diagnosis of ACOS were selected.They were divided into two groups according to the different treatment drugs:Sulidide combined with Tiotropium Bromide inhalation group(experimental group,60 cases)and Sulidide inhalation group(control group,40 cases).The pulmonary function indexes were compared before and after treatment.The scores of asthma symptom,chronic obstructive pulmonary symptom and acute exacerbation were compared between the two groups before and after treatment,and the occurrence of adverse reactions in the two groups was compared.Results There was no significant difference in lung function between the two groups before treatment(P>0.05).After treatment,the lung function of the two groups was improved,but the lung function index of the experimental group was better than that of the control group after treatment,the differences were statistically significant(P<0.05).ACT,CAT,COPD score and acute exacerbation times showed no significant difference between the two groups before treatment(P>0.05).ACT,CAT of two groups after treatment were significantly decreased,the frequency of acute exacerbation was significantly reduced,but the experimental group after treatment score and acute exacerbation times were better than the control group,the differences were statistically significant(P<0.05).The incidence of adverse drug reactions in the experimented group was lower than that of the control group,the difference was statistically significant(P<0.05).Conclusion The effects of Sulidide inhalation combined with Tiotropium Bromide in ACOS are good,and the prognosis of patients can be improved.