超敏C反应蛋白及尿酸对2型糖尿病合并脑梗死患者的诊治价值

Value of high-sensitivity C-reactive protein and uric acid in diagnosis and treatment of type 2 diabetes complicated with cerebral infarction

目的探讨超敏C反应蛋白(hs-CRP)及尿酸(UA)在2型糖尿病合并脑梗死诊治中的临床价值,为2型糖尿病合并脑梗死的预防和治疗提供参考依据。方法选取2015年2月至2017年2月收治的初次发病的2型糖尿病合并脑梗死患者117例,分别进行颈动脉彩超检测、美国国立卫生研究院卒中量表(NIHSS)评分检测和头颅核磁共振检查(MRI),并分别检测并比较不同亚型患者的血清hs-CRP、UA水平差异。结果不稳定斑块组、稳定斑块组患者hs-CRP及UA水平明显高于无斑块组,差异有统计学意义(P<0.05);不稳定斑块组血清hs-CRP及UA水平明显高于稳定斑块组,差异有统计学意义(P<0.05);神经功能重度缺损组患者血清hs-CRP及UA水平显著高于神经功能轻度缺损组,差异有统计学意义(P<0.05);大面积梗塞组患者血清hs-CRP及UA水平明显高于小面积梗塞组,差异有统计学意义(P<0.05)。结论血清hs-CRP及UA水平可作为反映2型糖尿病合并脑梗死患者临床诊疗的重要指标,对于2型糖尿病合并脑梗死的预防和治疗有重大意义。

Objective To explore the clinical value of different serological indicators in the diagnosis and treatment of type 2 diabetes mellitus with type 2 diabetes mellitus(T2DM)complicated with cerebral infarction,and to provide reference for prevention and treatment of type 2 diabetes mellitus complicated with cerebral infarction.Methods A total of 117 patients with type 2 diabetes mellitus complicated with cerebral infarction were enrolled in this study from February 2015 to February 2017.The patients were divided into two groups:the carotid artery ultrasonography,the NIHSS score test hypersensitive C-reactive protein(hs-CRP)and uric acid(UA)in patients with different subtypes were measured and compared with those of different subtypes.Results The levels of hs-CRP and UA in patients with unstable plaque group and stable plaque group were significantly higher than those without plaque group(P<0.05).The levels of hs-CRP and UA in unstable plaque group were significantly higher(P<0.05).The levels of serum hs-CRP and UA in patients with severe neurological deficit were significantly higher than those in patients with mild neurological deficit(P<0.05).The difference was statistically significant(P<0.05).The levels of serum hs-CRP and UA in the large infarct group were significantly higher than those in the small infarct group(P<0.05).Conclusion Serum hs-CRP and UA can be used as an important indicator of clinical diagnosis and treatment of patients with type 2 diabetes mellitus complicated with cerebral infarction.It is of great significance for the prevention and treatment of type 2 diabetes mellitus complicated with cerebral infarction.