老年2型糖尿病患者应用二甲双胍前后血清胱抑素C水平的变化

The level of serum cystatin C before and after the treatment of metformin in elderly T2DM patients

目的 观察老年2型糖尿病患者应用二甲双胍前后血清胱抑素C水平的变化。方法 对2012年至2015年12月在该院住院并使用二甲双胍的95例老年糖尿病患者的临床资料进行回顾性分析,观察二甲双胍治疗前后空腹血糖、糖化血红蛋白、血清胱抑素C、血肌酐、血尿素氮、肝功等指标的变化。结果 本组老年2型糖尿病患者服用二甲双胍治疗时间≥6个月,单用二甲双胍治疗者10例(10.5%),联合其他口服降糖药物者28例(29.5%),单独联合胰岛素治疗者18例(18.9%),同时联合其他口服药及胰岛素治疗者39例(41.1%),均能有效降低空腹血糖及HbA1c水平。整组人群比较二甲双胍治疗前后血清胱抑素C、血肌酐、血尿素氮、肝功水平无明显变化,无乳酸酸中毒发生。结论 老年T2DM患者应用二甲双胍降糖效果良好且较为安全,年龄并非二甲双胍治疗的禁忌证。

Objective To evaluate the levels of serum cystatin C before and after the treatment of metformin in elderly T2DM patients.Methods Ninety-five cases of elderly T2DM hospitalized in the hospital from Jan.2012 to Dec.2015 were reviewed;the changes of fasting blood glucose,glycosylated hemoglobin,serum cystatin C,creatinine,urea,liver function were evaluate before and after treatment.Results The time of treatment with metformin was all longer than 6 months in these cases.The levels of FBG and HbA1c significantly reduced after treatment with metformin only in 10 cases(10.5%),metformin combined with other oral hypoglycemic drugs in 28 cases(29.5%),metformin combined with insulin only in 18 cases(18.9%)and metformin combined with other oral hypoglycemic drugs and insulin in 39 cases(41.1%).The serum cystatin C,creatinine,urea and liver function had no significant change after treatment in total cases,and no lactic acidosis occured.Conclusion Metformin is safe and effective in the treatment of elderly T2DM patients.Ageing is not the contraindication of metformin.