摘要
目的 分析盐城地区某医院2013-2016年3种抗癫痫药物的血药水平监测情况,为临床合理用药提供参考。方法 采用回顾性研究方法,对该院2013-2016年3种常用抗癫痫药物(丙戊酸钠、卡马西平、苯妥英钠)血药水平监测数据进行统计、分析。结果 2013-2016年本院AEDs血药水平监测例次总体呈上升趋势,共监测1 020次;其中丙戊酸钠840次,卡马西平135次,苯妥英钠25次;监测结果在有效血药水平范围内的共计553次(54.22%);>18~60岁的中青年患者监测例次最多,占44.22%;接受单药治疗的住院患者共监测438次,其中丙戊酸钠、卡马西平、苯妥英钠血药水平监测结果在治疗窗内的比例分别为53.80%、42.55%、20.00%,差异具有统计学意义(P<0.05)。23例联合用药的住院患者中,抗癫痫药血药水平均在治疗窗内的有6例(26.09%)。结论 血药水平监测对于癫痫患者实施个体化给药具有重要意义。该院AEDs血药水平监测工作仍存在诸多不足,有待进一步改进。
Objective To analyze the blood concentration monitoring of 3 kinds of antiepileptic drugs(AEDs)in a hospital from 2013 to 2016 in order to provide reference for rational use of drugs in clinic.Methods A retrospective investigation and analysis was used to classify monitoring data of the blood concentration of 3 kinds of AEDs in the hospital from 2013 to 2016.Results The number of AEDs blood concentration monitoring cases increased year by year.Among the total 1 020 cases,860 were sodium valproate(VPA),135 were carbamazepine(CBZ)and 25 were phenytoin(PHT).553(54.22%)cases were in the effective plasma concentration range.The main objects of blood concentration monitoring were young and middle-aged(range from 18 to 60),accounting for 44.22%.Among 438 cases receiving single drug therapy,the rates of serum concentrations of VPA,CBZ and PHT in therapeutic window were 53.80%,42.55%and 20.00%,with statistical significance different(P<0.05).Among 23 hospitalized receiving combination therapy,6(26.09%)cases were both in therapeutic window.Conclusion It is of great importance to monitor the blood concentration of anti-epilepsies drugs to provide the individual administration for patients.There are still some problems of AEDs blood concentration in our hospital,and deficiencies needed to be solved and improved.
作者
缪阳
卞海林
张婷
祁旺
张琳琳
MIAO Yang;BIAN Hailin;ZHANG Ting;QI Wang;ZHANG Linlin(Department of Pharmacy,the First People′s Hospital of Yancheng,Yancheng,Jiangsu 224000,China)
出处
《检验医学与临床》
CAS
2018年第A01期27-30,共4页
Laboratory Medicine and Clinic
关键词
抗癫痫药
血药水平监测
丙戊酸钠
卡马西平
苯妥英钠
antiepileptic drugs
blood concentration monitoring
sodium valproate
carbamazepine
phenytoin