探讨白细胞介素-23和白细胞介素-17在小儿哮喘患者中的作用

To explore the role of IL-23 and IL-17 in children with asthma

目的 探讨白细胞介素(IL)-23和IL-17在小儿哮喘患者外周血的表达,分析二者的相互关系及其与哮喘严重程度之间的联系。方法 选择该院住院小儿哮喘患者50例,按照病情评估进行分组,轻度哮喘组15例,中度哮喘组22例,重度哮喘组13例,对照组选择健康小儿30例。收集小儿外周血,采用酶联免疫吸附试验测定血清IL-23和IL-17水平,采用Spearman相关分析IL-23和IL-17之间的相关性。结果 哮喘患儿血清IL-23和IL-17水平较对照组明显升高,差异有统计学意义(P<0.05),且随着哮喘病变的加剧逐渐增加。结论 IL-23和IL-17在小儿哮喘患者中表达明显增加,并且与疾病严重程度存在相关性,有助于哮喘的诊断和预后判断。

Objective To investigate the expression of IL-23 and IL-17 in patients with childhood asthma and the correlations with asthma severity.Methods 50 children with asthma were involved in this study,they were divided into mild group(n=15),moderate group(n=22)and severe group(n=13)according to assessment of the disease,30 cases of healthy children in the control group.Serum concentration of Interleukin(IL)-23 and IL-17 were analyzed by ELISA.Spearman was employed to analyze correlations.Results Serum IL-23 and IL-17 in patients with asthma were higher than that in health controls,differences are statistically significant(P<0.05),and correlated to the severity of asthma.Conclusion High levels of IL-23 and IL-17 were found in patients with childhood asthma,and correlated with asthma severity.This play important roles in diagnosis and prognosis of childhood asthma.