热休克蛋白的功能及其在畜牧业中的应用

The function and application of heat shock protein in animal breeding and veterinary medicine

作为分子伴侣,热休克蛋白(HSP)可以参与到各种生命活动中。其最主要的功能是帮助错误折叠蛋白回到原来的状态,维持细胞的稳态。很多研究都表明HSP可以参与免疫、抗氧化、抗辐射以及抗癌细胞增殖中。在畜禽养殖过程中,动物遭受热应激时体内HSP均会有不同程度的表达,HSP的表达量与细胞损伤程度成反比。因此提示其可能对动物抵抗应激具有重要作用。使用阿司匹林或辅酶Q10能在热应激状态下诱导HSP表达,从而帮助畜禽抵抗热应激,提高动物养殖效益。本文总结了前人关于HSP在不同领域的研究进展,热应激状态下畜禽体内HSP的表达情况,以及以HSP为指标筛选饲料添加剂抵抗热应激的效果等。

Heat shock proteins(HSP)can keep cell homeostasis and capture the wrong folding proteins back to normal state,which act as molecular chaperone from bacteria to human under stress conditions.HSP participate in nearly all vital activities such as immune function,anti-oxidative,anti-radiation and cancer cell proliferation et al.Expression of different Hsps during stress varies depending on their protective functions and anti-apoptotic activities.When livestock under heat stress,HSP expressed differently,suggesting their protective role.Adding aspirin or coenzyme Q10 and other substance to animal feed could upregulate HSP expression under heat stress,suggesting these feed supplements could improve stress tolerance in animals,and improve the efficiency of animal breeding and decrease the cost.In the present review,we summarized the findings of previous research on the application of HSP in human area and veterinary medicine,and the current feed supplyments anti-stress activities,for better animal welfare and food safty in future.