瑞芬太尼联合羟考酮对颅脑肿瘤手术患者的麻醉效果及其MMSE评分的影响

Anesthetic Effect of Remifentanil Combined with Oxycodone in the Operation of Patients with Brain Tumor and its Effect on MMSE Score

目的探讨颅脑肿瘤患者手术中应用瑞芬太尼联合羟考酮的麻醉效果以及对患者MMSE评分的影响。方法选取我院收治的134例颅脑肿瘤患者为研究对象,随机分为研究组与对照组,每组67例。对研究组患者应用瑞芬太尼联合羟考酮进行麻醉处理,对照组应用瑞芬太尼进行麻醉处理,观察两组患者的呼吸恢复时间、睁眼时间、拔管时间、MMSE评分以及患者对麻醉处理方法的满意度等情况。结果治疗后研究组患者的MMSE评分显著优于对照组(P<0.05);研究组患者的呼吸恢复时间、睁眼时间、拔管时间均明显少于对照组(P<0.05);研究组患者的满意度为94.1%,对照组患者的满意度为76.1%,研究组显著高于对照组(P<0.05);研究组患者的心率与平均动脉压较对照组术中波动更小(P<0.05)。结论颅脑肿瘤手术患者采用瑞芬太尼联合羟考酮进行麻醉处理,不仅具有稳定患者脑血流动力学,还具有降低疾病对患者认知功能影响的作用,值得在临床推广应用。

Objective To investigate the anesthetic effect and the effect on MMSE score of remifentanil combined with oxycodone in the surgical patients with brain tumor.Methods 134 patients with brain tumor were studied,randomly divided into the study group and the control group,67 cases per group.The patients in the study group were treated with remifentanil combined with oxycodone,and those in the control group were treated with remifentanil anesthesia.The respiration recovery time,the eyes-open time,the extubation time,the MMSE score and the patient's satisfaction to the anesthesia treatment were observed.Results After treatment,the MMSE score of patients was significantly better than that in the control group(P<0.05).As for the anesthetic effect,patients in the study group had less respiratory recovery time,eyes-open time,extubation time than those in control group(P<0.05).The satisfaction degree of patients in the study group was 94.1%,and that in the control group was 76.1%.The satisfaction degree of the study group was significantly higher than that of the control group(P<0.05).Patients of the study group had less score in heart rate and mean arterial pressure fluctuation than those of the control group(P<0.05).Conclusion The use of remifentanil combined with oxycodone in the treatment of brain tumors not only played the role in stabilizing cerebral hemodynamics,but also reduced impairment on cognitive function of patients.It is worth popularizing and applying in clinic.