肿瘤Notch信号通路的研究进展

Research progress of Notch signaling pathway in tumor

Notch基因编码一类高度保守的细胞表面受体,决定胚胎发育和成熟组织中的细胞命运,是相邻细胞之间通讯进而调控细胞发育、增殖和凋亡的重要通路。多种肿瘤的发生与进展和Notch信号通路异常有关。针对不同肿瘤,有效调控靶向Notch的参与者与靶分子,对抗肿瘤治疗具有重要研究意义。

Notch gene encodes a class of highly conserved cell surface receptors that determine the fate of cells in embryonic development and mature tissue,which is an important pathway of communication between adjacent cells,and then regulates of cell development,proliferation and apoptosis.The occurrence and progression of multiple tumors are associated with abnormal Notch signaling pathways.For different tumors,it is important significance for anti-tumor therapy to effectively regulate the Notch participants and target molecules.