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桧木醇的合成新工艺研究 被引量：4

Study on Synthetic New Technology of Hinokitol
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摘要 以环戊二烯在金属钠作用下与异丙基溴发生烷基化反应得到1-异丙基环戊二烯,然后在二氯乙酰氯发生加成反应得到7,7-二氯-3-异丙基-双环[3,2,0]庚-2-烯-6-酮,最后发生扩环反应得到桧木醇。 In this paper,alkylation of cyclopentadiene with isopropyl bromide gives 1-isopropyl cyclopentadiene under sodium,then an addition reaction with dichloroacetyl chloride gives 7,7-dichloro-3-Isopropyl-bicyclo[3,2,0]hept-2-en-6-one.Finally it undergoes a ring expansion reaction to give Hinokitol.
作者 刘玮 樊振 李宏卫 马珍珍 姜玉钦 Liu Wei;Fan Zhen;Li Hongwei;Ma Zhenzhen;Jiang Yuqin(China Pharmaceutical Health Industry Co.,Ltd.,Beijing 100061,China;Topfond Pharmaceutical Co.,Ltd.,Zhumadian 463000,China;School of Chemistry and Chemical Engineering,Henan Engineering Research Center of Chiral Hydroxyl Pharmaceuticals,Henan Normal University,Xixiang 453007,China)
机构地区 中国医药健康产业股份有限公司 天方药业有限公司 河南师范大学化学化工学院
出处 《山东化工》 CAS 2018年第12期33-34,共2页 Shandong Chemical Industry
关键词 钠 烷基化反应 桧木醇 sodium alkylation reaction hinokitol
分类号 O623.6 [理学—有机化学]
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  • 2TANAKA T, MUTO N, IDO Y, et at. Induction of embryonal carcinoma cell differentiation by deferoxamine, a potent therapeutic iron chelator [ J ] . Biochim Biophys Acta, 1997, 1357(1): 91-97.
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  • 7SHIH Y H, LIN D J, CHANG K W, et al. Evaluation physical characteristics and comparison antimicrobial and anti- inflammation potentials of dental root canal sealers containing hinokitio| in vitro [ J ] . PLoS One, 2014, 9(6): e94941.
  • 8WANG W K, LIN S T, CHANG W W, et al. Hinokitiol induces autophagy in murine breast and colorectal cancer ceils [ J ] . EnvironToxicol, 2014. doi: 10.1002/tox.22023. [Epubahead of print ].
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山东化工
2018年 第12期

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