艾司西酞普兰对儿童青少年强迫障碍的疗效

Efficacy of escitalopram in the treatment for children and adolescents with obsessive-compulsive disorder

目的探讨艾司西酞普兰治疗儿童青少年强迫障碍的有效性和安全性,为儿童青少年强迫障碍的药物治疗提供参考。方法选取2010年1月-2012年12月在北京大学第六医院就诊的符合《国际疾病分类(第10版)》(ICD-10)诊断标准的强迫障碍儿童青少年患者50例,给予艾司西酞普兰治疗6周。在治疗前及治疗第2、6周后,采用耶鲁-布朗强迫症状量表(Y-BOCS)评定疗效,采用副反应量表(TESS)及实验室检查评定安全性。结果治疗2周后,患者Y-BOCS评分平均减分率32.5%,进步46例,无效4例;治疗6周后,患者Y-BOCS评分平均减分率54.1%,显著进步42例,进步8例。治疗期间,所有患者均未出现严重不良反应,实验室检查未见明显异常。结论艾司西酞普兰治疗儿童青少年强迫障碍起效较快,随着用药时间的延长,对强迫症状的改善效果可能更好,安全性较好。

Objective To explore the safety and efficacy of escitalopram in the treatment for children and adolescents with obsessive-compulsive disorder(OCD),to provide references for drug treatment of children and adolescents with OCD.Methods 50 children and adolescents were recruited from The Peking University Sixth Hospital during January 2010 to December 2012.All subjects met diagnosis of OCD according to International Classification of Diseases,tenth edition(ICD-10).They were treated by escitalopram for 6 weeks.Before treatment and after treatment for 2,6 weeks,the efficacy was evaluated by Yale-Brown Obsessive Compulsive Scale(Y-BOCS),and the safety was evaluated by Treatment Emergent Symptom Scale(TESS)and laboratory examination.Results After treatment for 2 weeks,the average score-reducing rate of Y-BOCS was 32.5%,46 cases improvement and 4 cases inefficiency.After treatment for 6 weeks,the average score-reducing rate of Y-BOCS was 54.1%,42 cases significant improvement and 8 cases improvement.Duration of trial,no obvious adverse events was observed,and laboratory examination showed little abnormal.Conclusion Escitalopram is effective for children and adolescents with OCD,the improvement may be getting better with the extension of medication time,less adverse reactions and slight.