运动对抑郁障碍治疗的协同作用

Synergistic effect of exercise on patients with depressive disorder

目的探讨运动对抑郁障碍治疗的协同作用,探索抗抑郁治疗新方向。方法连续纳入60例符合《国际疾病分类(第10版)》(ICD-10)抑郁障碍诊断标准并接受规范用药的患者,采用微信监督运动并随访6周,按运动是否达标分为运动组(n=35)和对照组(n=25)。于基线期和干预6周后采用汉密尔顿抑郁量表17项版(HAMD-17)、汉密尔顿焦虑量表(HAMA)、自尊量表(SES)和一般自我效能感量表(GSES)进行评定。结果干预6周后,运动组和对照组HAMA评分差异有统计学意义(t=-6.40,P=0.040),HAMD-17评分差异无统计学意义(t=-0.34,P=0.720);运动组HAMD-17和HAMA评分减分率≥25%的人数比例均高于对照组(χ~2=5.93、6.25,P均<0.05);两组GSES评分比较差异有统计学意义(F=0.52,P=0.001);两组腰围比较差异有统计学意义(F=8.22,P=0.006)。结论运动干预联合药物治疗较单用药物治疗可能更有助于改善抑郁障碍患者的抑郁、焦虑症状及自我效能感。

Objective To explore the synergistic effect of exercise on the treatment of depression disorder and explore the new direction of anti-depression treatment.Methods Sixty consecutive patients diagnosed with depressive disorder based on International Classification of Diseases,tenth edition(ICD-10)were enrolled in the study.WeChat was used to supervise the exercise and follow up for 6 weeks.According to whether the exercise was up to the standard or not,60 patients were divided into the exercise group(n=35)and the control group(n=25).At the baseline and after intervention for 6 weeks,Hamilton Depression Scale-17 item(HAMD-17),Hamilton Anxiety Scale(HAMA),Self-Esteem Scale(SES)and General Self-Efficacy Scale(GSES)were adopted to assess the two groups.Results After the intervention for 6 weeks,there was a statistically significant difference in HAMA scores between the exercise group and the control group(t=-6.40,P=0.040).The difference of HAMD-17 scores of the two groups was not statistically significant(t=-0.34,P=0.720).The proportion of those whose HAMD-17 and HAMA scores reduction rates were above 25%of the exercise group was higher than those of the control group(χ2=5.93,6.25,all P<0.05).The difference of GSES scores between the two groups was statistically significant(F=0.52,P=0.001).The difference in waist circumference between the two groups was statistically significant(F=8.22,P=0.006).Conclusion Regular exercise might be associated with facilitated medical management of depressive disorder in terms of improving depression,anxiety symptoms and self-efficacy.