DNA甲基化在病理性瘢痕中的作用研究

Study on the Role of DNA Methylation in Pathological Scars

病理性瘢痕是指烧伤、创伤和手术等后创面过度修复引起,以胶原等大量细胞外基质产生与沉积失衡为特征的皮肤纤维增生性疾病,包括增生性瘢痕与瘢痕疙瘩等。随着对增生性瘢痕研究的不断深入,人们发现DNA甲基化在瘢痕形成的发生和发展过程中起着重要的作用。本文就DNA甲基化在病理性瘢痕中作用的研究进展进行综述。

Pathological scars are caused by excessive repair of wounds after burn,trauma,and surgery,which are caused by a large amount of extracellular matrix produced by collagen and other extracellular matrix,including hyperplastic scar and keloid.With the development of hypertrophic scar,DNA methylation plays an important role in the occurrence and development of scar formation.This article reviews the research progress of the role of DNA methylation in pathological scars.