COPD加重期患者肺功能、血气指标及炎症指标的变化分析

Changes of Pulmonary Function,Blood Gas and Inflammation in Patients with COPD Exacerbation

目的研究慢性阻塞性肺疾病急性加重期患者的肺功能指标、血气以及炎性指标的变化,为临床制定诊疗方案提供参考依据。方法将我院2014年1月~2016年10月呼吸内科收治的42例慢阻肺急性加重期患者纳入A组,对其采用相应的治疗措施,另选取42例同期收治的慢阻肺稳定期患者纳入B组,并选取同期42例正常体检者为对照组。对三组患者的肺功能指标、血气分析以及炎性指标进行分析对比。结果 A组、B组三项指标均比正常体检者低,差异有统计学意义(P<0.05);A组三项指标均低于B组,差异有统计学意义(P<0.05);血气指标、炎性因子表达变化与急性加重期患者肺功能改变均具有相关性(P<0.05)。结论急性加重期患者肺功能、血气及炎性指标与其他分期或健康者有较大的差异,在临床上需要对病情进行详尽分析,确定合适的治疗方案。

Objective To study the changes of pulmonary function,blood gas and inflammatory indexes in patients with acute exacerbation of chronic obstructive pulmonary disease(COPD)and to provide reference for clinical diagnosis and treatment.Methods 42 patients with acute exacerbation of COPD admitted in our hospital from January 2014 to October 2016 were included in group A and treated with corresponding treatment measures.Another 42 patients with stable chronic obstructive pulmonary disease admitted in the same period were included in the group B.42 cases of normal physical examination were selected as control group in the same period.Pulmonary function index,blood gas analysis and inflammatory index were analyzed and compared among the three groups.Results The three indexes of group A and group B were lower than those in normal physical examination,the difference is statistically significant(P<0.05).The three indexes of group A were lower than those in group B,the difference is statistically significant(P<0.05).The changes of blood gas index,inflammatory factor expression and pulmonary function were correlated with acute exacerbation(P<0.05).Conclusion The pulmonary function,blood gas and inflammatory indexes in patients with acute exacerbation are different from those in other stages or healthy persons.It is necessary to make a detailed analysis of the condition in clinical practice and determine the appropriate treatment plan.