生酮饮食对不同病因及发作形式儿童难治性癫痫疗效差异的临床观察

Clinical Observation of the Effect of Ketogenic Diet on the Efficacy of Children with Refractory Epilepsy Due to Different Causes and Attacks

目的观察生酮饮食治疗不同病因及发作形式小儿难治性癫痫疗效的差异。方法选取2012年8月~2017年3月我院使用生酮饮食治疗3个月以上的65例难治性癫痫患儿,根据病因随访坚持生酮饮食情况,记录生酮饮食期间患儿治疗3个月后癫痫发作情况。结果 31例症状性癫痫患儿中,有效16例(51.61%),34例不明原因癫痫患儿中,有效25例(73.53%),两者比较差异无统计学意义(P>0.05)。35例单一发作患儿中,有效23例(65.71%),30例混合发作患儿中,有效18例(60.00%),两者比较差异无统计学意义(P>0.05)。14例婴儿痉挛发作患儿中,有效12例(85.71%),51例非痉挛发作患儿中,有效29例(56.86%),两者比较差异有统计学意义(P<0.05)。结论生酮饮食治疗不同病因难治性癫痫有效性不受病因影响,对婴儿痉挛效果更加显著。

Objective To observe the differences in the efficacy of ketogenic diet in the treatment of children with intractable epilepsy.Methods 65 children with intractable epilepsy who had been treated with ketogenic diet for more than three months in our hospital from August 2012 to March 2017 were selected.According to the etiology follow-up adherence to the ketogenic diet,record seizures after 3 months of treatment in children with ketogenic diet.Results Of the 31 children with symptomatic epilepsy,16(51.61%)were effective,and of the 34 children with unexplained epilepsy,25(73.53%)were effective.There was no significant difference between the two groups(P>0.05).Of the 35 children with single-onset epilepsy,23(65.71%)were effective,and in 30 mixed seizures,18(60.00%)were effective.There was no significant difference between the two groups(P>0.05).Of the 14 infants with infantile spasm,12(85.71%)were effective,Of the 51 children with non-deaf seizures,29(56.86%)were effective,and there was a statistically significant difference between the two groups(P<0.05).Conclusion The effectiveness of ketogenic diet in treating different causes of refractory epilepsy is not affected by the etiology,and the effect on infantile spasm is more significant.