不孕不育患者解脲脲支原体培养及耐药性分析

Analysis of Culture and Drug Resistance of Ureaplasma Urealyticum in Infertility Patients

目的研究不孕不育患者解脲脲支原体感染及对药物的耐药性。方法回顾分析2016年1月~2017年12月在南华大学附属常德医院诊治的94例不孕不育患者和40例已生育健康者的临床资料,对比两组解脲脲支原体感染情况。结果不孕不育组男性、女性解脲脲支原体感染率分别为13例(30.95%)、21例(40.38%),高于对照组的2例(12.50%)、4(16.67%),差异有统计学意义(P<0.05);94例不孕不育患者共检出68株解脲脲支原体,对解脲脲支原体培养,敏感性较高的为四环素、强力霉素、交沙霉素、美满霉素、克拉霉素、阿奇霉素,耐药性最高的是诺氟沙星。结论不孕不育患者解脲脲支原体感染率较高可能是不孕不育的主要因素,临床可将其检测作为临床筛查的内容。同时治疗解脲脲支原体感染,应依据药敏试验结果选择敏感性高的抗生素,以提高临床治疗效果。

Objective To study Ureaplasma urealyticum infection and drug resistance in infertility patients.Methods The clinical data of 94 infertile patients and 40 fertile healthy subjects treated in Changde Hospital affiliated to Nanhua University from January 2016 to December 2017 were retrospectively analyzed.The infection of Ureaplasma Urealyticum was compared between the two groups.Results Male and female infertility group infection of Ureaplasma urealyticum were 13 cases(30.95%),21 cases(40.38%),more than 2 cases of control group(12.50%),4(16.67%),the difference was statistically significant(P<0.05);94 cases of infertility patients were detected in 68 strains of Ureaplasma urealyticum and Ureaplasma culture urealyticum,high sensitivity to tetracycline,doxycycline,josamycin,minocycline,clarithromycin,azithromycin,the highest resistance to norfloxacin.Conclusion The high infection rate of Ureaplasma urealyticum in infertility patients may be the main factor of infertility,and clinical detection can be used as the content of clinical screening.At the same time,the treatment of Ureaplasma urealyticum infection should be based on drug sensitivity test results to select high-sensitivity antibiotics to improve clinical treatment.