多发性骨髓瘤患者校正血钙的临床分析

Clinical Analysis of Corrected Serum Calcium in Patients with Multiple Myeloma

目的分析我院多发性骨髓瘤患者校正前后血钙的差异,及校正后血钙与疾病的相关性。方法回顾性分析我院2011年1月~2017年5月确诊的58例初发多发性骨髓瘤患者实验室检查、影像学检查等临床资料,对其血清白蛋白、血钙水平、血红蛋白、血肌酐、β2-微球蛋白、血清LDH、溶骨性病变等多项指标进行分析。结果经血清白蛋白公式校正后D-S分期Ⅲ期的患者高钙血症发生率比较正前升高,Ⅰ期、Ⅱ期校正前后血钙差异无统计学意义(P>0.05);高钙组血清LDH、溶骨性病变均高于非高钙组,差异有统计学意义(P<0.05),而两组血红蛋白、肌酐、β2-微球蛋白相比,差异无统计学意义(P>0.05);肾功能不全组血钙升高明显,校正后血钙更能准确提示患者病情严重程度。结论多发性骨髓瘤校正后的血钙更能真实反映与之相符的疾病状态下真实的血钙水平,更能有效预测病情严重程度。

Objective To analyze the difference of serum calcium in patients with multiple myeloma before and after correction,and the correlation between serum calcium and disease.Methods The clinical data of 58 patients with primary multiple myeloma,which were confirmed in our hospital from January 2011 to May 2017,were analyzed.The clinical data such as serum albumin,blood calcium,hemoglobin,serum creatinine,β2-microglobulin,serum LDH,and osteolytic disease were analyzed.Results After correction of serum albumin formula,the incidence of hypercalcemia in patients with D-S stageⅢwas higher than that in non-hypercalcemia group,and there was no significant difference in serum calcium before and after correction in stageⅠand stageⅡ(P>0.05),and the serum LDH and osteolytic lesions in high calcium group were higher than those in non-hypercalcemia group,the difference was statistically significant(P<0.05),but there was no significant difference in hemoglobin,creatinine andβ2-microglobulin between the two groups(P>0.05).The blood calcium level in the renal insufficiency group was significantly increased.After correction,blood calcium could more accurately indicate the severity of the disease.Conclusion The corrected serum calcium level of multiple myeloma can reflect the true level of serum calcium in accordance with the disease and predict the severity of the disease more effectively.