硝苯地平联合厄贝沙坦治疗糖尿病合并高血压的疗效观察

Efficacy of Nifedipine Combined with Irbesartan in the Treatment of Diabetes Complicated with Hypertension

目的探讨硝苯地平联合厄贝沙坦治疗糖尿病合并高血压的临床疗效。方法选取2016年2月~2017年2月我院收治的糖尿病合并高血压患者共68例,按照随机数字抽签法分为对照组和观察组,每组34例。对照组给予厄贝沙坦治疗,观察组使用硝苯地平联合厄贝沙坦治疗,比较两组患者治疗总有效率、血压及24 h尿微量清蛋白指标。结果观察组治疗总有效率为94.12%,高于对照组的67.65%,差异有统计学意义(P<0.05)。治疗后,观察组患者的舒张压、收缩压、24 h尿微量清蛋白等指标均优于对照组,差异具有统计学意义(P<0.05)。观察组患者的药物不良反应与对照组比较,差异无统计学意义(P>0.05)。结论硝苯地平联合厄贝沙坦治疗糖尿病合并高血压患者,临床疗效显著,能改善患者血压,降低24 h尿微量清蛋白,具有积极的临床推广价值。

Objective To investigate the clinical efficacy of nifedipine combined with irbesartan in the treatment of diabetes complicated with hypertension.Methods A total of 68 diabetic patients with hypertension were selected from February 2016 to February 2017 in our hospital.According to the method of random number drawing,they were divided into control group and observation group with 34 cases in each group.The control group was treated with irbesartan,the observation group was treated with nifedipine combined with irbesartan.The total effective rate,blood pressure and 24 h urinary microalbumin were compared between the two groups.Results The total effective rate of the observation group was 94.12%,higher than that of the control group 67.65%,the difference was statistically significant(P<0.05).After treatment,the diastolic blood pressure,systolic blood pressure,and 24 h urine microalbumin were all better in the observation group than those in the control group,and the difference was statistically significant(P<0.05).There was no significant difference in adverse drug reactions between the observation group and the control group(P>0.05).Conclusion Nifedipine combined with irbesartan in the treatment of diabetic patients with hypertension has a significant clinical effect.It can improve the blood pressure and reduce the microalbumin in 24 h urine.It has a positive clinical value.