摘要
High linear energy transfer radiation is known to deposit higher energy in tissues and cause greater damage than low-LET irradiation[1].Local immunosuppression is frequently observed after irradiation(IR).Dendritic cells(DCs)play important roles in the initiation and maintenance of the immune response[2].The dysfunction of DCs contributes to tumor evasion and growth.However,molecular mechanisms underlying the establishment of immune tolerance induced by heavy ion IR through this DC population are poorly understood.
