非小细胞肺癌患者经皮微波消融术后肿瘤相关性死亡危险因素

Risk factors of tumor related death in patients with non-small cell lung cancer after percutaneous microwave ablation

目的探讨经皮微波消融术后的非小细胞肺癌患者发生肿瘤相关性死亡的危险因素。方法回顾研究在我科行经皮微波消融术的70例非小细胞肺癌患者,对其年龄、性别、肿瘤分期等一般因素进行单因素、Logistic分析,以期发现肿瘤相关性死亡的危险因素。结果单因素分析示,瘤直径<3 cm与≥3 cm患者的生存率分别为81.8%(9/11)、40.7%(24/59),接受辅助治疗与非接受辅助治疗患者的生存率分别为58.3%(21/36)、29.4%(10/34),差异有统计学意义(P<0.05)。多因素分析示,非小细胞肺癌患者微波消融术后肿瘤相关性死亡的重要危险因素为肿瘤分期、肿瘤直径与术后辅助治疗(均P<0.05)。结论正确掌握肿瘤分期、直径的大小、积极的术后辅助治疗能减少患者经皮微波消融术后肿瘤相关性死亡的风险。

Objective To investigate the risk factors of tumor related death in patients with non-small cell lung cancer after percutaneous microwave ablation.Methods A retrospective analysis of 70 cases of non-small cell lung cancer patients undergoing percutaneous microwave ablation was conducted.Single factor and logistic anal-ysis were performed for the risk factors of tumor related death.Results The single factor analysis showed that sur-vival rate of patients with tumor diameter<3 cm and≥3 cm was 81.8%(9/11)and 40.7%(24/59)respectively and that of patients receiving adjuvant treatment and those receiving no adjuvant treatment was 58.3%(21/36),and 29.4%(10/34)respectively and the differences were statistically significant(P<0.05).Multivariate analysis showed that the important risk factors of tumor related death after percutaneous microwave ablation were tumor stage,tumor diameter and postoperative adjuvant treatment(all P<0.05).Conclusion Cancer staging,diame-ter,and positive postoperative adjuvant therapy can reduce the risk of tumor related death after percutaneous micro-wave ablation.