基质金属蛋白酶-2与冠状动脉粥样硬化性疾病的研究进展

Progress of the Researchon Matrix Metalloproteinase-2 and Coronary Atherosclerotic Disease

基质金属蛋白酶-2是基质金属蛋白家族中的一个重要成员,在生理情况下参与人体的正常发育,病理状态下潜在基质金属蛋白酶-2被激活,通过削减斑块纤维帽参与心室重构在多种心血管疾病的发生、发展中起重要作,并且有望成为反映心血管疾病的一种生物标志物,而对基质金属蛋白酶-2的调节将是一个可能的治疗靶点。现就基质金属蛋白酶-2的基因、蛋白、活性调节、信号转导及其在冠状动脉粥样硬化性心脏病中的研究进展予以综述。

Matrix metalloproteinase-2 is an important member of matrix metalloprotein family,it is involved in the normal development of human body under physiological conditions.And activated in pathological state,by reducing plaque fibrous cap and ventricular remodeling plays an important role in the development of various cardiovascular diseases,and is expected to become a biomarker reflecting cardiovascular disease.The regulation of matrix metalloproteinase-2 may be a possible therapeutic target.Now the gene,protein,regulation of its activity and signal transduction of matrix metalloproteinase-2 and its application in coronary atherosclerotic heart disease are reviewed.