整合素α_6β_1和CD44V4在卵巢上皮癌中表达及相关性分析

Expression and Correlation of Integrin α_6β_1 and CD44V4 in Epithelial Ovarian Carcinoma

目的通过检测上皮癌病理组织及正常卵巢组织中整合素α_6β_1和CD44V4表达情况,探讨其表达特点与临床病理特征的相关性。方法收集2015年1月~2016年12月手术切除的20例正常卵巢组织、40例卵巢上皮良性肿瘤及65例卵巢上皮癌组织,利用免疫组织化学法检测整合素α_6β_1和CD44V4的表达水平,结合病理组织特征进行相关性分析。结果卵巢上皮癌组织中整合素α_6β_1和CD44V4的表达水平显著高于正常卵巢及上皮良性肿瘤组织,差异有统计学意义(P<0.05),且在不同病理分期及分化程度的卵巢上皮癌组织之间的差异有统计学意义(P<0.05);但在不同组织学分型病理组织中差异无统计学意义(P>0.05);α_6β_1和与CD44V4在卵巢上皮癌组织中的表达存在明显正相关(r=0.599,P<0.05)。结论整合素α_6β_1和与CD44V4在卵巢上皮癌组织中高表达且有相关性,可作为卵巢上皮癌发展的分子标志物。

Objective To detect the expression of integrinα6β1 and CD44V4 in epithelial carcinoma and normal ovarian tissues,and to explore the correlation between the expression of integrinα6β1 and clinicopathological features.Methods 20 cases of normal ovarian tissue,40 cases of ovarian epithelial benign tumor and 65 cases of epithelial ovarian cancer surgically resected from January 2015 to December 2016 were collected.The expression of integrinα6β1 and CD44V4 were detected by immunohistochemistry.Tissue characteristics for correlation analysis.Results The expression of integrinα6β1 and CD44V4 in ovarian epithelial carcinoma was significantly higher than that in normal ovarian and benign epithelial tumors,the difference was statistically significant(P<0.05),there was a statistically significant difference in epithelial ovarian cancer between different pathological stages and differentiation degree(P<0.05),but there was no significant difference in pathological histology among different histological types(P>0.05).There was a significant positive correlation betweenα6β1 and CD44V4 expression in epithelial ovarian cancer(r=0.599,P<0.05).Conclusion The expression of integrinα6β1 and CD44V4 in epithelial ovarian cancer are highly correlated and may be used as molecular markers for the development of epithelial ovarian cancer.