酒石酸布托啡诺、氟比洛芬酯、芬太尼联合异丙酚镇痛镇静对ICU内机械通气患者的疗效比较

Comparison of Analgesic Effects of Butorphanol Tartrate Flurbiprofen and Fentanyl Combined with Propofol in Patients undergoing Mechanical Ventilation in ICU

目的研究ICU内机械通气患者酒石酸布托啡诺、氟比洛芬酯、芬太尼联合异丙酚镇痛镇静疗效比较。方法选取2015年5月~2017年5月在我院ICU病房接受机械通气治疗的135例患者,将患者随机分三组,各组45例,A组酒石酸布托啡诺+异丙酚,B组氟比洛芬酯+异丙酚,C组芬太尼+异丙酚,比较组间生命体征指标及镇痛、镇静评分。结果 A、B组用药后1h及2h的HR、RR、MAP均比C组低(P<0.05);A组FPS评分、Ramsay评分分较B组、C组低,差异有统计学意义(P<0.05)。结论联合应用酒石酸布托啡诺、异丙酚可有效稳定ICU机械通气患者生命体体征。

Objective To compare the analgesic and sedative effects of butorphanol tartrate flurbiprofen and fentanyl combined with propofol in patients undergoing mechanical ventilation in ICU.Methods From May 2015 to May 2017,135 patients who received mechanical ventilation in our ICU ward were randomly divided into three groups,45 patients in each group.Group A:Butorphanol tartrate+Propofol;Group B:Flurbiprofen axetil+Propofol;Group C:Fentanyl+Propofol;Vital signs,sedation and sedation scores were compared among groups.Results The HR,RR and MAP of group A and group B were lower than those of group C at 1 h and 2 h(P<0.05).The scores of FPS and Ramsay in group A were lower than those in group B and group C,the difference was statistically significant(P<0.05).Conclusion The combination of butorphanol tartrate and propofol can effectively stabilize the vital signs of ICU patients with mechanical ventilation.