血液灌流联合血液滤过在重症胰腺炎患者中的疗效及预后影响研究

Study on Curative Effect and Prognosis of Hemoperfusion Combined with Hemofiltration in Patients with Severe Pancreatitis

目的探讨血液灌流联合血液滤过在重症胰腺炎患者中的临床效果及对预后的影响。方法取2015年1月~2016年12月医院收治重症胰腺炎患者60例,随机数字法分为对照组和观察组,各30例。对照组采用常规方法治疗,观察组采用血液灌流联合血液滤过治疗,采用SF-36生活质量评分量表对两组治疗前、治疗后生活质量进行评估,比较两组临床疗效。结果观察组治疗后腹痛缓解、首次排便、血淀粉酶恢复正常、住院时间,均短于对照组(P<0.05)。两组患者治疗过程中未出现并发症,对比差异无统计学意义(P>0.05)。两组治疗前SF-36生活质量评分无统计学意义(P>0.05);观察组治疗后SF-36生活质量评分高于对照组(P<0.05)。结论重症胰腺炎患者采用血液灌流联合血液滤过治疗效果理想,能改善患者预后,有助于改善患者生活质量,值得推广应用。

Objective To investigate the clinical effect of hemoperfusion combined with hemofiltration in patients with severe pancreatitis and its influence on prognosis.Methods From January 2015 to December 2016,60 patients with severe pancreatitis were randomly divided into control group(n=30)and observation group(n=30).The control group was treated with routine methods,while the observation group was treated with hemoperfusion combined with hemofiltration.The SF-36 quality of life scale was used to assess the quality of life before and after treatment in both groups,and the clinical efficacy was compared between the two groups.Results In the observation group,abdominal pain relief,first defecation,blood amylase returned to normal and hospital stay were shorter than those in the control group(P<0.05).There was no complication in the two groups during treatment,the difference was not statistically significant(P>0.05).The quality of life of SF-36 before treatment in both groups was not significantly different(P>0.05).The quality of life of SF-36 in observation group was higher than that in control group after treatment(P<0.05).Conclusion Severe acute pancreatitis using hemoperfusion combined with hemofiltration is effective and can improve the prognosis of patients and help to improve the quality of life of patients,which is worth popularizing and applying.