糖化血红蛋白、血同型半胱氨酸在非糖尿病性急性脑梗死患者中的水平变化及其临床意义

The Level Changes and Clinical Significance of Glycosylated Hemoglobin and Blood Homocysteine in Patients with Non-Diabetic Acute Cerebral Infarction

目的研究糖化血红蛋白、血同型半胱氨酸在非糖尿病性急性脑梗死患者中的水平变化及意义。方法选取非糖尿病性急性脑梗死患者120例作为观察组,并根据入院当天的NIHSS评分分为轻、中、重度脑梗死组。选取同期健康体检者60例作为对照组。比较不同神经功能缺损程度的非糖尿病性急性缺血性脑梗死患者的糖化血红蛋白及血同型半胱氨酸水平,并与健康对照组比较。结果急性缺血性脑梗死患者糖化血红蛋白及血同型半胱氨酸水平均高于健康对照组,且糖化血红蛋白及血同型半胱氨酸水平随神经功能缺损程度升高而增高,差异有统计学意义(P<0.05)。结论非糖尿病性急性脑梗死患者糖化血红蛋白及血同型半胱氨酸水平与与神经功能缺损程度密切相关。

Objective To study the changes and significance of glycosylated hemoglobin and homocysteine in non-diabetic acute cerebral infarction patients.Methods 120 patients with non-diabetic acute cerebral infarction were selected as observation group and were divided into mild,moderate and severe cerebral infarction group according to NIHSS score at the admission day.Select the same period of 60 healthy subjects as a control group.To compare the levels of glycosylated hemoglobin and homocysteine in patients with non-diabetic acute ischemic cerebral infarction with different degrees of neurological impairment.Results The levels of glycosylated hemoglobin and homocysteine in patients with acute ischemic cerebral infarction were all higher than those in healthy controls,and the level of glycosylated hemoglobin and homocysteine increased with the increase of neurological deficit.The difference was statistically significant(P<0.05).Conclusion The levels of glycosylated hemoglobin and homocysteine in patients with non-diabetic acute cerebral infarction were closely related to the degree of neurological impairment.