围术期输血对胃癌根治术患者预后及免疫的影响

Effect of Perioperative Blood Transfusion on Prognosis and Immunity of Patients with Radical Gastrectomy

目的观察围术期输血对胃癌根治术患者的临床效果,分析其对患者预后及机体免疫的影响。方法回顾性研究2009年4月~2012年11月收治的100例胃癌根治术患者,依据围术期有无输血记录,分为两组,即甲组(47例)与乙组(53例),甲组接受输血,乙组未接受输血,观察分析输血对患者预后及免疫的影响。结果对于5年生存率,甲组为48.94%,乙组为64.15%,组间差异具有统计学意义(P<0.05)。经免疫学检测,组间CD3、CD4、CD8以及Leu-7值无显著差异(P>0.05),术后3 y,乙组CD4^+/CD8^+明显高于甲组,差异具有统计学意义(P<0.05)。结论胃癌根治术围手术期输血患者CD4^+/CD8^+低于未输血患者,易引起免疫抑制。

Objective To observe the clinical effect of perioperative blood transfusion on gastric cancer patients,analyze its impact on the prognosis of patients and body immunity.Methods A retrospective study of the April 2009~2012 year in November 100 cases of gastric cancer patients,on the basis of perioperative blood transfusion records,divided into two groups:group A(47 cases)and group B(53 cases),group A received blood transfusion,group B did not receive blood transfusion,observe and analyze the effect of blood transfusion on prognosis and immune patients.Results The 5-year survival rate was 48.94%in group A and 64.15%in group B,with significant difference between groups(<0.05).The immunological detection,group CD3,CD4,CD8 and Leu-7 value had no significant difference(>0.05),3 months after surgery,group B CD4+/CD8+was significantly higher than that in group A,the difference was statistically significant(<0.05).Conclusion CD4+/CD8+in perioperative patients with gastric cancer undergoing radical operation is lower than that in patients without blood transfusion,which may cause immunosuppression.