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安喘至圣膏治疗慢性阻塞性肺疾病稳定期肺肾阴虚证临床研究 被引量:5

Clinical Study on Anchuan Zhisheng Ointment for Treatment of Chronic Obstructive Pulmonary Disease with Lung-kidney Yin Deficiency Syndrome
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摘要 目的观察安喘至圣膏治疗慢性阻塞性肺疾病(COPD)稳定期肺肾阴虚证临床疗效。方法按就诊先后顺序将100例患者随机分为观察组和对照组各50例。2组均予布地奈德福莫特罗粉吸入剂,每次2吸,每日2次,饭前吸入,连续6个月。观察组并予安喘至圣膏,每次10 g,每日2次,早晚温服,连续3个月。观察2组治疗前及治疗3、6个月时中医症状积分、COPD评估测试(CAT)评分及肺功能情况。结果与本组治疗前比较,2组治疗3、6个月中医症状积分显著降低(P<0.05);2组治疗不同时点比较,观察组治疗3、6个月中医症状积分显著低于对照组(P<0.05)。与本组治疗前比较,2组治疗3、6个月CAT评分显著降低(P<0.05);2组治疗不同时点比较,观察组治疗3个月CAT评分显著低于对照组(P<0.05)。与本组治疗前比较,2组治疗3、6个月第1秒用力呼气容量(FEV1)、第1秒用力呼气容量占用力肺活量百分比(FEV1/FVC)显著改善(P<0.05);2组治疗不同时点比较,观察组治疗3个月FEV1、FEV1/FVC显著优于对照组(P<0.05)。结论安喘至圣膏可有效改善COPD稳定期肺肾阴虚证患者的临床症状,改善肺功能。 Objective To investigate the clinical efficacy of Anchuan Zhisheng Ointment in treatment of chronic obstructive pulmonary disease(COPD)with lung-kidney yin deficiency syndrome.Methods Totally 100 cases of COPD with lung-kidney yin deficiency syndrome were randomly divided into observation group and control group according to the order of visits.Both groups were given budesonide formoterol powder inhaler,2 breaths each time,twice daily,inhaled before meals,for 6 months.The observation group was given Anchuan Zhisheng Ointment additionally,10 g each time,twice daily,orally and warmly taken in the morning and evening,for 3 months.TCM symptom scores,CAT scores,and lung function before and 3 and 6 months of treatment in both groups were observed.Results Compared with before treatment,TCM symptom scores at 3 and 6 months of treatment in both groups were significantly lower(P<0.05);Comparing the two groups at different time points,TCM symptom scores in the observation group at 3 and 6 months of treatment were significantly lower than those in the control group(P<0.05).Compared with before treatment,CAT scores at 3 and 6 months of treatment in both groups were significantly lower(P<0.05);Comparing the two groups at different time points,CAT scores in the observation group at 3 months of treatment were significantly lower than those in the control group(P<0.05).Compared with before treatment,the percentages of forced expiratory volume(FEV1)in the 1st second and FEV1/FVC at 3 and 6 months of treatment in both groups were significantly improved(P<0.05).Comparing the two groups at different time points,FEV1 and EV1/FVC in the observation group at 3 months of treatment were significantly better than those in the control group(P<0.05).Conclusion Anchuan Zhisheng Ointment can effectively improve the clinical symptoms of COPD patients with lung-kidney yin deficiency syndrome and lung function.
作者 杨立春 陈晶晶 吴玲 YANG Li-chun;CHEN Jing-jing;WU Ling(Changji Chinese Medicine Hospital,Changji 831100,China)
机构地区 昌吉州中医医院
出处 《中国中医药信息杂志》 CAS CSCD 2018年第8期21-24,共4页 Chinese Journal of Information on Traditional Chinese Medicine
基金 昌吉州科技局项目(2016S09-07)
关键词 安喘至圣膏 肺肾阴虚证 慢性阻塞性肺疾病 Anchuan Zhisheng Ointment lung-kidney yin deficiency syndrome chronic obstructive pulmonary disease
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