生活方式与肌萎缩侧索硬化症发病相关性分析

Association analysis between lifestyle and amyotrophic lateral sclerosis:a case-control study

目的探讨吸烟、饮酒、饮茶等生活方式与罹患肌萎缩侧索硬化症的相关性。方法选择2016年4月1日至2017年1月30日就诊的复旦大学附属华山医院92例肌萎缩侧索硬化(ALS)患者(病例组),以及按性别、年龄以1∶4与病例组匹配的江苏省泰州市自然人群368例对照组,通过病例对照研究,分析生活方式如吸烟、饮酒、饮茶情况与ALS患病的关系,再采用meta分析方法定量分析国内外发表的ALS患病与生活方式相关性的同类研究。结果病例对照分析结果显示,两组在吸烟情况和有无饮茶习惯方面比较,差异均无统计学意义(P>0.05),而meta分析结果与之一致;饮酒与降低患ALS的风险相关(OR=0.515,95%CI 0.325~0.818),而meta分析结果(OR=0.77,95%CI 0.60~0.97)与其有差异。结论吸烟、饮茶与ALS的患病风险的相关性未得到证实。饮酒可能与降低ALS患病风险相关,过量的体力活动可能与增加ALS患病风险相关。

Objective To investigate the relationship between smoking,drinking,drinking tea and other lifestyle factors and amyotrophic lateral sclerosis.Methods A total of 92 cases of amyotrophic lateral sclerosis(ALS)in Huashan Hospital Affiliated to Fudan University from April 1,2016 to January 30,2017 were selected,and 368 cases of natural population in Taizhou,Jiangsu,which were matched by sex,age and 1 to 4,were matched by a case control study to analyze the living ways of the disease,such as smoking,drinking,drinking tea and ALS.Meta analysis was used to quantitatively analyze the relationship between ALS prevalence and lifestyle.Results The results of case control analysis showed that there was no significant difference in smoking and tea drinking habits between the two groups(P>0.05),but the results of meta analysis were the same.Alcohol consumption was associated with reducing the risk of ALS(OR=0.515,95%CI 0.3250.818),and meta analysis(OR=0.77,95%CI 0.600.97).Conclusion The association between smoking,drinking tea and the risk of ALS has not been confirmed.Alcohol consumption is associated with reducing the risk of ALS,and excessive physical activity is associated with increasing the risk of ALS.