实验性家兔股动脉切开置球囊管与股动脉穿刺置球囊管成功率对比分析

Comparative Analysis of the Success Rate of Rabbit Femoral Artery Incision with Balloon Catheter and Femoral Artery Puncture with Balloon Catheter

目的:探讨股动脉切开与股动脉穿刺置球囊管成功率。方法:选取健康雄性新西兰兔20只,随机平均分为股动脉切开组与股动脉穿刺组,各10例。股动脉切开组采取股动脉切开探查后直视下置入球囊制作腹主动脉球囊损伤模型,股动脉穿刺组采取股动脉穿刺置入球囊制作腹主动脉球囊损伤模型。比较两组球囊损伤成功率、死亡率、造模时间、术后进食及内膜增生情况。结果:股动脉切开组造模时间长于股动脉穿刺组(P<0.05);两组进食时间、成功率、死亡率、新生内膜厚度、血管平均狭窄程度、平滑肌细胞层厚度比较,差异均无统计学意义(P>0.05),其中股动脉切开组成功率达100%,股动脉穿刺组成功率90.0%。结论:本研究两种方法均有稳定可靠、方法简单、易于复制、花费时间短等优点,可以模拟临床中的相关问题,是PCI术后再狭窄研究中较理想的动物模型。

Objective:To investigate the success rate of femoral artery incision and femoral artery puncture with balloon catheter.Method:The 20 healthy male New Zealand rabbits were selected,randomly divided into femoral artery incision group and femoral artery puncture group,10 cases in each group.The femoral artery incision group was performed open femoral artery exploration,and then the balloon injury model was established under direct vision.The femoral artery puncture group was implanted into the balloon by femoral artery puncture to make the abdominal aortic balloon injury model.The success rate,mortality,modeling time,postoperative feeding and intimal hyperplasia between two groups were compared.Result:The modeling time in femoral artery incision group was longer than that of femoral artery puncture group(P<0.05).The eating time,success rate,mortality rate,neointimal thickness,mean vessel stenosis and smooth muscle cell layer thickness in two groups were compared,the difference was not statistically significant(P>0.05),and the success rate of femoral artery incision group was 100%,femoral artery puncture group was 90.0%.Conclusion:The two methods in this study have the advantages of stability,reliability,simple method,easy replication,and short duration of time,can simulate the relevant problems in the clinic and are ideal animal models for restenosis after PCI.