紫杉醇联合卡铂对于晚期三阴性乳腺癌治疗效果分析

Analysis of Efficacy of Paclitaxel Combined with Carboplatin in Treatment of Advanced Triple Negative Breast Carcinoma

目的:探讨紫杉醇联合卡铂对三阴性乳腺癌(triple negative breast carcinoma,TNBC)的临床治疗效果。方法:选取本院2015年1-12月收治的92例晚期TNBC患者。按照随机数字表法将其分为观察组(紫杉醇联合卡铂治疗)和对照组(紫杉醇治疗),各46例,治疗4个疗程后观察两组治疗效果、不良反应,比较两组Kamofsky评分、无进展生存期(progression-free-survival,PFS)及总生存期(over survival,OS)。结果:治疗周期结束后,观察组总有效率高于对照组(P<0.05);两组恶心呕吐、腹泻、肝功能损害、血小板减少、中性粒细胞减少的发生率比较,差异均无统计学意义(P>0.05);观察组Kamofsky评分、PFS、OS均优于对照组,比较差异均有统计学意义(P<0.05)。结论:紫杉醇联合卡铂治疗晚期TNBC具有良好的临床治疗效果,值得临床推广关注。

Objective:To explore the clinical effect of Paclitaxel combined with Carboplatin in treatment of advanced triple negative breast carcinoma(TNBC).Method:A total of 92 patients with advanced TNBC were treated in our hospital from January to December 2015.According to the random number table method,they were divided into observation group(Paclitaxel combined with Carboplatin treatment)and control group(Paclitaxel treatment),46 cases in each group,after 4 courses of treatment,the therapeutic effects and adverse reactions of two groups were observed,and the Kamofsky score,progression-free-survival(PFS),over survival(OS)oftwo groups were compared.Result:After treatment,the total effective rate of observation group was higher than that of control group(P<0.05).The incidence of nausea and vomiting,diarrhea,liver function impairment,thrombocytopenia and neutrophilia between two groups were compared,the differences were not statistically significant(P>0.05).The Kamofsky score,PFS and OS of observation group were all better than those of control group,the differences were statistically significant(P<0.05).Conclusion:Paclitaxel combined with Carboplatin in treatment of advanced TNBC has a good clinical effect and is worthy of clinical attention.