青皮注射液对局灶脑缺血再灌注损伤的治疗作用

Protective effect of injection of qingpi on focal cerebral ischemia and reperfusion damage

目的 观察青皮注射液对大鼠局灶性脑缺血再灌注损伤的脑保护作用。方法 采用大鼠局灶性脑缺血再灌注模型 ,32只大鼠随机分为对照组和青皮注射液治疗组 ;观察两组神经功能缺失体征评分和脑梗塞体积。结果 青皮组注射液组神经功能缺失评分为 (2 .1 30± 0 .991 )分 ,对照组为 (3 .1 30± 0 .756)分 ,青皮注射液组神经功能缺失体征评分明显低于对照组 (P <0 .0 5) ;青皮组注射液组对照组脑梗死体积为 (2 31 .85± 80 .1 4 )mm3,对照组为 (41 0 .81± 89.43)mm3,青皮注射液组脑梗死体积明显低于对照组 (P <0 .0 1 )。

Objective To investigate the protection of injection of qingpi during focal cerebral ischemia and reperfusion in rats.Methods 32 rats were randomly divided into control group (n=16) and qingpi group (n=16),and the infarct size was observed using the rat model of focal cerebral ischemia and reperfusion.Results The neurological deficit scale of qingpi group was (2.130±0.991),and the control group was (3.130±0.756),the infarct size of Qingpi group was (231.85±80.14) mm 3,and the control group was (410.81±89.43) mm 3.Compared with the control group,the neurological deficit scales and the infarct size were significantly lower in the qingpi group(P<0.05).Conclusion Injection of qingpi could provide cerebral protection during focal cerebral ischemia and reperfusion in rats.