摘要
目的:观察早期肉毒素A局部注射对降低额部瘢痕增生的效果。方法:40例需要行额部肿物切除手术的患者随机分成两组,在术后72h内注射或不注射肉毒素A(BTXA)。对患者进行为期1年的随访,使用患者瘢痕评估量表(PSAS)、温哥华瘢痕量表(VSS)以及视觉模拟量表(VAS)对术后切口瘢痕进行评估打分。结果:在1年的随访中,36例患者被复查,4例患者失访。两组之间在PSAS方面没有统计学差异(P>0.05)。而肉毒素A治疗组的VSS及VAS评分与对照组相比结果均具有统计学差异(P<0.05),表明术后肉毒素A注射有降低瘢痕增生的作用。结论:由于可以抑制肌肉收缩而降低伤口局部张力,因此注射肉毒素A可以降低瘢痕增生的程度从而改善额部伤口缝合后的美容效果。
Objective:To observe the effect of early local injection of botulinum toxin(BTA)A on reducing hypertrophic scar in the frontal area.Methods:Forty patients who required a nephrectomy surgery were enrolled in this study.They were divided into two groups,with or without BTA injection within 72 hours after surgery.The patients were followed for a period of one year.Postoperative scars were scored using the Patient Scar Rating Scale(PSAS),Vancouver scar scale(VSS)and the Visual Analogue Scale(VAS).Results:During the 1-year follow-up,36 patients were reviewed and 4 patients were lost.There was no statistically significant difference in the PAS between the two groups.However,the score of VAS and VSS between treatment group and the control group has a statistically significant difference,demonstrating that postoperative BTA injection has a role in reducing scar hyperplasia.Conclusion:By inhibiting muscle contraction and reducing the local tension of the wound,injection of BTA can reduce the scar hyperplasia and improve the cosmetic outcome of the forehead wound.
作者
陶谏
刘宾
汪阳
崔鑫
韩悦
Tao Jian;Liu Bin;Wang Yang(Department of Burn and Plastic Surgery of Xi’an Center Hospital(Xi’an 710003))
出处
《陕西医学杂志》
CAS
2018年第8期1011-1013,共3页
Shaanxi Medical Journal
基金
陕西省科技厅社会发展攻关项目(2015SF-160)
关键词
瘢痕
肉毒杆菌毒素类
A型
额
Cicatrix
Botulinum toxins,type A
Forehead