奥氮平治疗对改善老年痴呆精神行为障碍的临床分析

Clinical analysis of olanzapine for improving the mental and behavioral disorders of senile dementia

目的:探讨奥氮平治疗对改善老年痴呆精神行为障碍的临床疗效。方法:收治老年痴呆精神行为障碍患者132例,随机分为两组。对照组给予利培酮治疗,观察组给予奥氮平治疗,比较两组临床疗效。结果:观察组总有效率明显高于对照组,差异有统计学意义(P<0.05)。治疗后,观察组血清总胆固醇、甘油三酯、空腹血糖高于对照组,差异有统计学意义(P<0.05)。结论:奥氮平治疗老年痴呆患者精神障碍的临床疗效显著。

Objective:To explore the clinical effect of olanzapine in improving the mental and behavioral disorders of senile dementia.Methods:132 cases of senile dementia patients with mental and behavioral disorders were divided into two groups randomly.The control group was treated with risperidone,and the observation group was treated with olanzapine.The clinical effect between groups was compared.Results:The total effective rate of the observation group was significantly higher than that of the control group,and the difference was statistically significant(P<0.05).After treatment,the serum total cholesterol,triglyceride and fasting blood glucose in the observation group were higher than those in the control group,and the difference was statistically significant(P<0.05).Conclusion:Olanzapine was effective in the treatment of mental disorders in senile dementia patients.