氯吡格雷联合阿司匹林对不稳定型心绞痛患者血液流变学的影响

Effect of clopidogrel combined with aspirin on hemorheology in patients with unstable angina pectoris

目的:探讨氯吡格雷联合阿司匹林治疗不稳定型心绞痛的效果。方法:收治不稳定型心绞痛患者98例,随机分为对照组和观察组,各49例。对照组给予阿司匹林治疗,观察组给予氯吡格雷与阿司匹林联合治疗。结果:观察组红细胞压积、血浆黏度、红细胞聚集指数均低于对照组(P<0.05);观察组疼痛持续时间短于对照组,心绞痛发作次数少于对照组,效果评分高于对照组(P<0.05)。结论:采用氯吡格雷与阿司匹林联合治疗不稳定型心绞痛患者,可有效改善血液流变学,利于减少心绞痛疼痛次数,缓解疼痛程度。

Objective:To explore the effect of clopidogrel combined with aspirin in the treatment of unstable angina pectoris.Methods:98 patients with unstable angina pectoris were selected.They were randomly divided into the control group and the observation group with 49 cases in each group.The control group was treated with aspirin,while the observation group was given clopidogrel combined with aspirin.Results:The hematocrit,plasma viscosity and erythrocyte aggregation index of the observation group were lower than that of the control group(P<0.05);the duration of pain in the observation group was shorter than that of the control group,and the frequency of angina pectoris was less than that of the control group,the score of the effect was higher than that of the control group(P<0.05).Conclusion:The combination of clopidogrel and aspirin in the treatment of patients with unstable angina pectoris can improve blood rheology effectively,reduce the number of pain in angina and relieve the pain.