血清sTREM-1和尿CAPAP对急性胰腺炎病情轻重与转归的评估

Evaluation of the severity and prognosis of acute pancreatitis by combined detection of serum sTREM-1 and urinary CAPAP

目的探讨sTREM-1及CAPAP对急性胰腺炎(acute pancreatitis,AP)病情轻重与转归的评估价值。方法选取2016年1月至2017年6月间我院收治的240例AP患者作为研究对象;使用酶联免疫吸附法(ELISA)检测血清中sTREM-1水平,采用胶体金法检测尿样中CAPAP水平;绘制ROC曲线分析sTREM-1和CAPAP对AP病情轻重与转归的评估价值。结果随着患者病情加重,患者血中sTREM-1及尿CAPAP阳性率均显著升高(P<0.05),且患者死亡率也随着病情加重而显著增加(P<0.05);死亡组患者血中sTREM-1水平及尿CAPAP阳性率均明显高于存活组,且差异有统计学意义(P<0.05);sTREM-1联合CAPAP评估患者病情的特异度及ROC曲线下面积均显著高于两项指标单独应用(P<0.05)。结论采用血清sTREM-1联合尿CAPAP对AP患者病情轻重与转归的评估具有较高的临床应用价值,其特异度及曲线下面积均明显高于sTREM-1或CAPAP单独应用。

Objectives To explore the value of sTREM-1 and CAPAP on the severity and prognosis of acute pancreatitis(AP).Methods A total of 240 patients diagnosed as AP were selected in this study from January 2016 to June 2017 in our hospital.The level of serum sTREM-1 was detected by enzyme-linked immunosorbent assay,and the level of urine CAPAP was detected by colloidal gold method.ROC curve was used to analyze the value of sTREM-1 and CAPAP on the severity and apoptosis of AP.Results With the aggravation of disease,the positive rate of sTREM-1 and urine CAPAP were significantly increased(P<0.05),and the mortality of patients with exacerbations was significantly increased(P<0.05).The level of sTREM-1 and urinary CAPAP positive rate in death group were significantly higher than the survival group,and the difference is statistical significance(P<0.05).The specificity and the area under ROC curve were significantly higher in combination of sTREM-1 and CAPAP than sTREM-1 and CAPAP alone(P<0.05).Conclusions The combination of serum sTREM-1 and urine CAPAP has higher clinical value in the evaluation for the severity and prognosis of AP patients,and the specificity and the area under the curve are significantly higher than those of sTREM-1 or CAPAP alone.