粪菌移植两种肠镜下盲肠置管术的对比研究

Comparison of two types of colonoscopyforfecal microbiota transplantation of cecal catheterization

目的探讨粪菌移植(FMT)在两种肠镜下盲肠置管术的临床应用。方法将2016年1月—2017年6月在我院通过肠镜下盲肠置管术进行粪菌移植的200例患者,随机分为A组和B组,各100例。A组采用直接肠镜置管法完成置管,B组采用二次肠镜置管法完成置管,对两组操作的置管成功率、置管时间、平均疼痛评分、并发症等情况进行对比。结果与A组相比较,B组到达盲肠时间略长但无统计学意义(14.95min vs15.26min,P=0.68)、疼痛评分低(5.7 vs 4.8,P<0.05)、更低的并发症发生率(6%vs 23%,P<0.05)。结论在粪菌移植内镜下盲肠置管术患者中,采用通过采用二次肠镜置管法与直接肠镜法相比较完成置管手术时间无统计学差异,但置管成功率高、患者的痛苦小、风险低,值得临床推广。

Objective To investigate the clinical application of fecal microbiota transplantation(FMT)in two kinds of colonoscopic cecal catheterization.Methods From January 2016 to June 2017,200 patients who took colonoscopic cecal catheterization for fecal microbiota transplantation in our hospital were randomly divided into group A and group B,with 100 patients in each group.Group A used direct colonoscopy catheterization to complete catheterization,group B was treated by the second colonoscopy catheterization.The success rate of catheterization,catheterization time,average pain score and complication were compared between the two groups.Results Compared with group A,the time to reach the cecum in group B was slightly longer but not statistically significant(14.95min vs 15.26min,P=0.68).It had lower pain score(5.7 vs 4.8,P<0.05),lower complication rate.Conclusion Among the patients with colonoscopic cecal catheterization for fecal microbiota transplantation,there was no significant difference in the time of catheterization between the second colonoscopy and the direct colonoscopy,but it has the high success rate of catheterization and low pain,low risk,worthy of clinical promotion.