汉族、维吾尔族老年男性2型糖尿病合并骨质疏松患者25羟维生素D水平分析

Analysis of 25 hydroxy vitamin D level for elderly male patients with T2DM complicated with osteoporosis in Hans and Uyghurs

目的分析25羟维生素D[25(OH)D]在新疆汉族及维吾尔族老年男性2型糖尿病(T2DM)合并骨质疏松(OP)患者中的水平及与骨密度(BMD)的相关性。方法收集住院的汉族、维吾尔族老年男性T2DM患者281例,根据民族及骨密度值将其分为汉族非骨质疏松(NOP)组127人(A组)、汉族骨质疏松(OP)组21人(B组)、维族NOP组103人(C组)、维族OP组30人(D组),记录四组患者的25(OH)D水平并进行比较,分析25(OH)D与BMD的相关性。结果同一民族中,B组的25(OH)D低于A组(P<0.05),D组的25(OH)D低于C组(P<0.05);T2DM合并OP患者中,D组的25(OH)D低于B组(P<0.05);相关性分析显示,25(OH)D与BMD呈正相关。结论维吾尔族老年男性T2DM合并OP患者较汉族患者的25(OH)D水平低,25(OH)D水平低的T2DM患者更易合并OP,25(OH)D检测有助于识别T2DM患者合并OP的风险。

Objective To analysis the level of 25 hydroxy vitamin D[25(OH)D]in Xinjiang Han and Uyghur elderly male patients with T2DM and osteoporosis,and the correlation between 25(OH)D levels and bone mineral density(BMD).Methods We collected 281 cases of T2DM patients from Hans and Uyghurs,divided them into four groups according to the nationality and BMD:Han non-osteoporosis(NOP)group including 127 cases(group A),Han osteoporosis(OP)group 21 cases(group B),Uyghur NOP group 103 cases(group C),Uyghur OP group 30 cases(group D).Recorded and compared their 25(OH)D levels,and analyzed the correlation between 25(OH)D levels and BMD.Results In the same nationality,the level of 25(OH)D in group B were lower than those in group A(P<0.05),and group D were lower than those in group C(P<0.05);In T2DM patients combined with OP,the levels of 25(OH)D in group D were lower than those in group B(P<0.05);Correlation analysis showed that 25(OH)D was positively correlated with BMD.Conclusion The level of 25(OH)D in elderly male patients with T2DM combined with osteoporosis,those of Uyghurs are lower than those of Hans.T2DM patients with lower 25(OH)D level are more likely to combine OP.The 25(OH)D level test may help to identify the risk of combining OP in T2DM patients.