广州地区老年人维生素D与骨密度、甲状旁腺激素的相关性研究

Study on the vitamin D status of elder people in Guangzhou and the relationship in vitamin D,bone mineral density and parathyroid hormone

目的探讨广州地区老年人维生素D水平及其与骨密度、甲状旁腺激素的相关性。方法收集2016年6月—12月在广州市第一人民医院老年病科就诊的患者。检测25-羟维生素D、甲状旁腺激素、Ⅰ型前胶原氨基端前肽、β-Ⅰ型胶原C端肽、腰椎和髋部骨密度。将患者分为维生素D缺乏组(≤20 ng/m L)、维生素D不足组(20~30 ng/m L)、维生素D充足组(≥30 ng/m L)。结果 (1)426例研究对象的平均年龄是(79.77±7.69)岁,25羟维生素D平均值是(20.38±8.20)ng/m L。维生素D缺乏、不足、充足者比例分别是53%(226/426)、34.3%(146/426)、12.7%(54/426)。(2)25羟维生素D水平随年龄增加而降低。25羟维生素D与股骨颈和全髋骨密度呈正相关(r=0.18,P<0.001),与甲状旁腺激素呈负相关(r=-2.05,P<0.001)。结论广州地区老年人维生素D不足及缺乏十分普遍。维生素D与股骨颈、髋部骨密度呈正相关,与甲状旁腺激素呈负相关。

Objective To investigate the vitamin D level of elder people in Guangzhou and the relationship in vitamin D,bone mineral density and parathyroid hormone.Methods To screening elderly patients in the geriatric department of Guangzhou First peoples Hospital from June to December 2016.Serum 25-hydroxy vitamin D,parathyroid hormone,procollagen typeⅠN-terminal propeptide,β-crosslaps of C-telopeptide of typeⅠcollagen,bone mineral density were measured.Three groups were divided according to the serum 25(OH)D level,including deficiency group(≤20 ng/mL),insufficiency group(20-30 ng/mL)and sufficiency group(≥30 ng/mL).Results The mean age of the 426 subjects was 79.77±7.69 years old.The average level of 25(OH)D was 20.38±8.20 ng/mL.The proportion of vitamin D deficiency,insufficient and sufficient persons were 53%(226/426),34.3%(146/426),and 12.7%(54/426).The level of 25 hydroxy vitamin D was decreased with age.Correlation analysis showed that 25 hydroxy vitamin D level was positive correlated with the femoral neck and total hip bone density(r=0.18,P<0.001),was negatively correlated with parathyroid hormone(r=-2.05,P<0.001).Conclusion Vitamin D deficiency or insufficiency is highly prevalent in elderly men in Guangzhou.25 hydroxy vitamin D level was positive correlated with the femoral neck and total hip bone density,negatively correlated with parathyroid hormone.