头孢菌素类抗菌素药物致药源性死亡的文献分析

Literature analysis of drug-induced deaths caused by cephalosporin antibiotics

目的:了解国内头孢菌素类抗菌素药物致药源性死亡的发生情况及相关特点,为预防药物不良反应,保证临床用药安全提供相关科学依据。方法:检索2007年1月1日~2016年12月31日中国生物医学文献数据库(CBMdisc)、中国知网(CNKI)和万方数据库(WFSD)中有关头孢菌素类抗菌药物致药源性死亡的相关文献,对致死病例相关信息,包括患者性别、年龄、原发疾病、临床症状、药物不良反应、死亡原因等信息进行回顾性收集。结果:75例病例中,男性44例(58.67%),女性31例(41.33%),平均年龄(47.2113.51)岁,70岁~年龄组死亡病例占比最高(20.00%)。病例的原发疾病主要以呼吸系统感染为主,其中肺部感染最多占33.33%(25/75)。给药方式以静脉给药为主占45.33%(34/75),其中静脉滴注27例(36.00%),静脉推注7例(9.33%),其次为口服给药占33.33%(25/75)。发生药源性死亡病例主要集中在用药后10min内,占57.33%(43/75)。过敏性休克是头孢菌素类抗菌药物致药源性死亡的最主要原因,占76.00%(57/75)。结论:临床用药过程中应当更加重视头孢菌素类抗菌药的临床用药监护,防止致死性病例的发生。

Objective:To understand the incidence and related characteristics of drug-induced deaths caused by cephalosporin antibiotics in China,and to provide scientific basis for the prevention of adverse drug reactions and guarantee the safety of clinical medication.Methods:Retrieval of cephalosporin-induced drug-induced deaths in China Biomedical Literature Database,China national knowledge internet and Wanfang Database from January 1,2007 to December 31,2016 Related information,including retrospective information about the patient's sex,age,primary disease,clinical symptoms,adverse drug reactions,the cause of death and other related information.Results:Among the 75 cases,there were 44 males(58.67%)and 31 females(41.33%),with an average age of(47.2113.51)years old,and the highest death rate was found in the age group of 70 years(20%).Respiratory infection was the main cause of the primary diseases,among which pulmonary infection was the most common(33.33%)(25/75).Intravenous administration was the main route of administration,accounting for 45.33%(34/75),including intravenous drip of 27 cases(36%),intravenous injection of 7 cases(9.33%),followed by oral administration(33.33%)(25/75).Drug-induced deaths were mainly concentrated in the 10min after treatment,accounting for 57.33%(43/75).Anaphylactic shock was the main cause of drug induced death due to cephalosporin antibiotics,accounting for 76%(57/75).Conclusion:In clinical medication,more attention should be paid to clinical monitoring of cephalosporin antibiotics to prevent the occurrence of fatal cases.